Serum Cingulin Levels Are Increased in Children with Autism Spectrum Disorder

Autor/inn/en	Artik, Abdülbaki; Isik, Ümit; Gündüz, Bahar Öztelcan; Mizrak, Soycan
Titel	Serum Cingulin Levels Are Increased in Children with Autism Spectrum Disorder
Quelle	In: International Journal of Developmental Disabilities, 69 (2023) 5, S.762-766 (5 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Artik, Abdülbaki)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	2047-3869
DOI	10.1080/20473869.2023.2200314
Schlagwörter	Autism Spectrum Disorders; Neurological Organization; Neuropsychology; Foreign Countries; Severity (of Disability); Genetics; Physiology; Correlation; Turkey; Childhood Autism Rating Scale + Suchen Sie Ihr Suchwort? Autism; Autismus; Neuropsychologie; Ausland; Schweregrad; Humangenetik; Physiologie; Korrelation; Türkei
Abstract	Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders in which the underlying pathogenesis and etiologic factors are not fully understood. The blood brain barrier (BBB) ??plays a critical role in central nervous system defense by limiting access to circulating solutes, macromolecules, and cells that can negatively affect neuronal activity. The loss of BBB integrity is likely to be seen as a common pathologic finding for many psychiatric disorders such as schizophrenia, ASD, and mood disorders. In this study, we aimed to investigate whether serum Cingulin levels are associated with ASD. Subjects and Methods: A total of 40 treatment-naive children with ASD and 40 healthy controls were included in the present study. The Schedule for Affective Disorders and Schizophrenia for School-Aged Children, Present and Lifetime Version-DSM-5 (K-SADS-PL-DSM-5) has been used to screen healthy controls for psychiatric disorders by a psychiatrist after a physical examination by a paediatrician. The clinical severity of the ASD symptoms has been assessed by the Childhood Autism Rating Scale (CARS). Venous blood samples were collected and serum Cingulin levels were measured. Results: When the ASD and control groups were compared, CARS and Cingulin values of the patient group were statistically higher than the healthy group. There is a statistically positive correlation between CARS and Cingulin values. Discussion: To the best of our knowledge, this study is a first in the literature conducted about the serum Cingulin levels, which is a component of BBB, among patients with ASD. Our findings demonstrate that serum Cingulin levels are meaningfully higher in ASD group compared to the healthy control group. It has been also indicated that there has been a meaningful relationship between serum Cingulin levels and ASD symptom severity. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01