Diversifying Autism Neuroimaging Research: An Arterial Spin Labeling Review

Autor/inn/en	Knudsen, Laust V.; Sheldrick, Abigail J.; Vafaee, Manouchehr S.; Michel, Tanja Maria
Titel	Diversifying Autism Neuroimaging Research: An Arterial Spin Labeling Review
Quelle	In: Autism: The International Journal of Research and Practice, 27 (2023) 5, S.1190-1203 (14 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Knudsen, Laust V.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/13623613221137230
Schlagwörter	Autism Spectrum Disorders; Brain Hemisphere Functions; Diagnostic Tests; Schemata (Cognition); Physiology; Measurement; Neurological Organization; Molecular Structure; Scientific Research; Neurosciences; Gender Differences; Age Differences + Suchen Sie Ihr Suchwort? Autism; Autismus; Diagnostic test; Diagnostischer Test; Cognition; Schema; Kognition; Physiologie; Messverfahren; Neuroscience; Neurowissenschaften; Neurowissenschaft; Geschlechterkonflikt; Age; Difference; Age difference; Altersunterschied
Abstract	Cognition and brain homeostasis depends on cerebral blood flow to secure adequate oxygen and nutrient distribution to the brain tissue. Altered cerebral blood flow has previously been reported in individuals diagnosed with autism spectrum condition in comparison to non-autistics. This phenomenon might suggest cerebral blood flow as a potential biomarker for autism spectrum condition. Major technological advancement enables the non-invasive and quantitative measurement of cerebral blood flow via arterial spin labeling magnetic resonance imaging. However, most neuroimaging studies in autistic individuals exploit the indirect blood oxygen level dependent functional magnetic resonance imaging signal instead. Therefore, this review examines the use of arterial spin labeling to further investigate the neurobiology of the autism spectrum condition. Followed by a comparison of results from molecular imaging and arterial spin labeling studies and a discussion concerning the future direction and potential of arterial spin labeling in this context. We found that arterial spin labeling study results are consistent with those of molecular imaging, especially after considering the effect of age and sex. Arterial spin labeling has numerous application possibilities besides the quantification of cerebral blood flow, including assessment of functional connectivity and arterial transit time. Therefore, we encourage researchers to explore and consider the application of arterial spin labeling for future scientific studies in the quest to better understand the neurobiology of autism spectrum condition. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01