Vulnerability to Early Stressful Life Events: The Moderating Role of HOMER1 Gene in the Gene x Environment Interaction

Autor/inn/en	Chen, Yidi; Wang, Lizhong; Jiang, Dongdong; Zhu, Shanshan; Research Team, WeGene; Chen, Gang; Gan, Yiqun
Titel	Vulnerability to Early Stressful Life Events: The Moderating Role of HOMER1 Gene in the Gene x Environment Interaction
Quelle	In: European Journal of Developmental Psychology, 20 (2023) 1, S.1-23 (23 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1740-5629
DOI	10.1080/17405629.2021.2011717
Schlagwörter	Foreign Countries; Early Experience; Stress Variables; At Risk Persons; Genetics; Coping; Environmental Influences; Adults; China + Suchen Sie Ihr Suchwort? Ausland; Frühbeginn; Risikogruppe; Humangenetik; Bewältigung; Environmental influence; Umwelteinfluss
Abstract	To explore the curvilinear relationship between early stressful life events and future-oriented coping and whether the "HOMER1" (rs7713917) polymorphism can moderate the relationship between early life stress and two types of future-oriented coping, 14,675 Han Chinese people were surveyed. The relationship between the number of early stressful life events and future-oriented coping adhered to a quadratic curve. "HOMER1" polymorphisms moderated the relationship between the impact of early life stress and preventive coping ([beta] = -0.02, 95% CI [-0.03, -0.01], p = 0.010), which was different from that of proactive coping ([beta] = -0.01, 95% CI [-0.02, 0.01], p = 0.073). Individuals with the AA genotype who experienced a high impact of early life stress were more likely to use preventive coping compared with those who experienced a low level of early life stress, but they showed no difference in their proactive coping strategies. In contrast, individuals with the GA/GG genotype displayed higher vulnerability to environmental changes. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01