Associations of a Metal Mixture with Iron Status in U.S. Adolescents: Evidence from the National Health and Nutrition Examination Survey

Autor/inn/en	Schildroth, Samantha; Friedman, Alexa; Bauer, Julia Anglen; Claus Henn, Birgit
Titel	Associations of a Metal Mixture with Iron Status in U.S. Adolescents: Evidence from the National Health and Nutrition Examination Survey
Quelle	In: New Directions for Child and Adolescent Development, (2022) 181-182, S.67-89 (23 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Schildroth, Samantha) ORCID (Friedman, Alexa) ORCID (Bauer, Julia Anglen) ORCID (Claus Henn, Birgit)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1520-3247
DOI	10.1002/cad.20457
Schlagwörter	Nutrition; National Surveys; Adolescent Development; Hazardous Materials; Correlation; Metallurgy; Bayesian Statistics; Cytology; Health + Suchen Sie Ihr Suchwort? Ernährung; Hazardous substance; Gefahrstoff; Korrelation; Hüttenwesen; Zytologie; Gesundheit
Abstract	Iron is needed for normal development in adolescence. Exposure to individual environmental metals (e.g., lead) has been associated with altered iron status in adolescence, but little is known about the cumulative associations of multiple metals with Fe status. We used data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) to examine associations between a metal mixture (lead, manganese, cadmium, selenium) and iron status in 588 U.S. adolescents (12-17 years). We estimated cumulative and interactive associations of the metal mixture with five iron status metrics using Bayesian Kernel Machine Regression (BKMR). Higher concentrations of manganese and cadmium were associated with lower log-transformed ferritin concentrations. Interactions were observed between manganese, cadmium, and lead for ferritin and the transferrin receptor, where iron status tended to be worse at higher concentrations of all metals. These results may reflect competition between environmental metals and iron for cellular uptake. Mixed metal exposures may alter normal iron function, which has implications for adolescent development. (As Provided).
Anmerkungen	Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01