Sulfotransferase Activity Contributes to Long-Term Potentiation and Long-Term Memory

Autor/inn/en	Sahoo, Biswaranjan; Sharma, Shiv K.
Titel	Sulfotransferase Activity Contributes to Long-Term Potentiation and Long-Term Memory
Quelle	In: Learning & Memory, 29 (2022) 6, S.155-159 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Long Term Memory; Biochemistry; Brain Hemisphere Functions; Spatial Ability; Stimuli + Suchen Sie Ihr Suchwort? Langzeitgedächtnis; Biochemie; Räumliches Vorstellungsvermögen; Anreizsystem
Abstract	A critical role of protein modifications such as phosphorylation and acetylation in synaptic plasticity and memory is well documented. Tyrosine sulfation plays important roles in several biological processes. However, its role in synaptic plasticity and memory is not well understood. Here, we show that sulfation contributes to long-term potentiation (LTP) in the hippocampal slices. In addition, inhibition of sulfation impairs long-term memory in a spatial memory task without affecting acquisition or short-term memory. Furthermore, LTP-inducing stimulus enhances protein tyrosine sulfation. These results suggest an important role for tyrosine sulfation in LTP and memory. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01