Acoustic Change over Time in Spastic and/or Flaccid Dysarthria in Motor Neuron Diseases

Autor/inn/en	Lévêque, Nathalie; Slis, Anneke; Lancia, Leonardo; Bruneteau, Gaëlle; Fougeron, Cécile
Titel	Acoustic Change over Time in Spastic and/or Flaccid Dysarthria in Motor Neuron Diseases
Quelle	In: Journal of Speech, Language, and Hearing Research, 65 (2022) 5, S.1767-1783 (17 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Lévêque, Nathalie) ORCID (Slis, Anneke)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Acoustics; Articulation Impairments; Diseases; Severity (of Disability); French; Foreign Countries; Speech Language Pathology; France + Suchen Sie Ihr Suchwort? Akustik; Artikulationsstörung; Disease; Krankheit; Schweregrad; Französisch; Ausland; Frankreich
Abstract	Purpose: This study aims to investigate acoustic change over time as biomarkers to differentiate among spastic-flaccid dysarthria associated with amyotrophic lateral sclerosis (ALS), spastic dysarthria associated with primary lateral sclerosis (PLS), flaccid dysarthria associated with spinal and bulbar muscular atrophy (SBMA), and to explore how these acoustic parameters are affected by dysarthria severity. Method: Thirty-three ALS patients with mixed flaccid-spastic dysarthria, 17 PLS patients with pure spastic dysarthria, 18 SBMA patients with pure flaccid dysarthria, and 70 controls, all French speakers, were included in the study. Speakers produced vowel-glide sequences targeting different vocal tract shape changes. The mean and coefficient of variation of the total squared change of mel frequency cepstral coefficients were used to capture the degree and variability of acoustic changes linked to vocal tract modifications over time. Differences in duration of acoustic events were also measured. Results: All pathological groups showed significantly less acoustic change compared to controls, reflecting less acoustic contrast in sequences. Spastic and mixed spastic-flaccid dysarthric speakers showed smaller acoustic changes and slower sequence production compared to flaccid dysarthria. For dysarthria subtypes associated with a spastic component, reduced degree of acoustic change was also associated with dysarthria severity. Conclusions: The acoustic parameters partially differentiated among the dysarthria subtypes in relation to motor neuron diseases. While similar acoustic patterns were found in spastic-flaccid and spastic dysarthria, crucial differences were found between these two subtypes relating to variability. The acoustic patterns were much more variable in ALS. This method forms a promising clinical tool as a diagnostic marker of articulatory impairment, even at mild stage of dysarthria progression in all subtypes. (As Provided).
Anmerkungen	American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01