Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

Autor/inn/en	Casey, S.; Carter, M.; Looney, A. M.; Livingstone, V.; Moloney, G.; O'Keeffe, G. W.; Taylor, R. S.; Kenny, L. C.; McCarthy, F. P.; McCowan, L. M. E.; Thompson, J. M. D.; Murray, D. M.
Titel	Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 9, S.3919-3932 (14 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Casey, S.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-05271-7
Schlagwörter	Mothers; Children; Autism; Pervasive Developmental Disorders; Metabolism; Pregnancy; Child Development + Suchen Sie Ihr Suchwort? Mother; Mutter; Child; Kind; Kinder; Autismus; Stoffwechsel; Schwangerschaft; Kindesentwicklung
Abstract	Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. [This article was written on behalf of the SCOPE Consortium.] (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01