Literaturnachweis - Detailanzeige
| Autor/inn/en | Zhu, Jiang; Hua, Xueying; Yang, Ting; Guo, Min; Li, Qiu; Xiao, Lu; Li, Ling; Chen, Jie; Li, Tingyu |
|---|---|
| Titel | Alterations in Gut Vitamin and Amino Acid Metabolism Are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder |
| Quelle | In: Journal of Autism and Developmental Disorders, 52 (2022) 7, S.3116-3128 (13 Seiten)
PDF als Volltext |
| Zusatzinformation | ORCID (Li, Tingyu) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0162-3257 |
| DOI | 10.1007/s10803-021-05066-w |
| Schlagwörter | Metabolism; Autism; Pervasive Developmental Disorders; Children; Interaction; Symptoms (Individual Disorders); Neurological Impairments |
| Abstract | Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. (As Provided). |
| Anmerkungen | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2024/1/01 |
Literaturbeschaffung und Bestandsnachweise in Bibliotheken prüfen
Permalink als QR-Code
Inhalt auf sozialen Plattformen teilen (nur vorhanden, wenn Javascript eingeschaltet ist)
Teile diese Seite:
