Literaturnachweis - Detailanzeige
| Autor/inn/en | Creighton, Samantha D.; Jardine, Kristen H.; Desimone, Alexa; Zmetana, Megan; Castellano, Sabrina; Milite, Ciro; Sbardella, Gianluca; Winters, Boyer D. |
|---|---|
| Titel | Age-Dependent Attenuation of Spatial Memory Deficits by the Histone Acetyltransferase P300/CBP-Associated Factor (PCAF) in 3XTG Alzheimer's Disease Mice |
| Quelle | In: Learning & Memory, 29 (2022) 3, S.71-76 (6 Seiten)
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| Zusatzinformation | ORCID (Creighton, Samantha D.) ORCID (Sbardella, Gianluca) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 1072-0502 |
| Schlagwörter | Alzheimers Disease; Animals; Research; Spatial Ability; Memory; Age Differences; Intervention; Biochemistry |
| Abstract | Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional manner. At 3 and 6 mo of age, PCAF activation ameliorated memory deficits. At 9 mo of age, PCAF activation had no effect on spatial memory, whereas PCAF inhibition improved memory deficits in females. This work reveals a complex potential therapeutic role for PCAF in AD, initially benefitting memory but becoming detrimental as the disease progresses. (As Provided). |
| Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2024/1/01 |
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