Neurodevelopment of HIV-Exposed Uninfected Children Compared with HIV-Unexposed Uninfected Children during Early Childhood

Autor/inn/en	Young, Julia M.; Bitnun, Ari; Read, Stanley E.; Smith, Mary Lou
Titel	Neurodevelopment of HIV-Exposed Uninfected Children Compared with HIV-Unexposed Uninfected Children during Early Childhood
Quelle	In: Developmental Psychology, 58 (2022) 3, S.551-559 (9 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Young, Julia M.) ORCID (Read, Stanley E.) ORCID (Smith, Mary Lou)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1649
DOI	10.1037/dev0001319
Schlagwörter	Acquired Immunodeficiency Syndrome (AIDS); Young Children; Foreign Countries; Child Development; Age Differences; Individual Development; Cognitive Ability; Cognitive Development; Intelligence Tests; Psychomotor Skills; Adjustment (to Environment); Canada; Wechsler Preschool and Primary Scale of Intelligence + Suchen Sie Ihr Suchwort? Frühe Kindheit; Ausland; Kindesentwicklung; Age; Difference; Age difference; Altersunterschied; Individuelle Entwicklung; Denkfähigkeit; Kognitive Entwicklung; Intelligence test; Intelligenztest; Psychomotorische Aktivität; Kanada
Abstract	HIV-exposed uninfected (HEU) children during the preschool and early school ages may be at-risk for neurodevelopmental challenges due to in utero and perinatal exposure to HIV and/or antiretroviral (ARV) medications. HEU children and HIV-unexposed uninfected (HUU) children from the community were recruited and tested at 3 to 4 and 5 to 6 years of age. Demographic information, HIV/ARV exposure and measures of intelligence, visuomotor skills, and adaptive functioning were obtained. Nonparametric tests assessed group differences and multiple regression analyses adjusted for demographic variables. Additional multiple regression analyses were performed within the HEU group to investigate associations between neurodevelopmental measures and variables of HIV/ARV exposure. At 3 to 4 years, 211 HEU children and 31 HUU children were assessed, and 144 HEU children and 58 HUU children were assessed at 5 to 6 years of age. At 3 to 4 years of age, HEU children scored significantly lower on measures of Full-Scale IQ, Performance IQ, visual motor integration, and adaptive functioning. At 5 to 6 years of age, HEU children scored significantly lower on all neurodevelopmental measures. At both ages, children who were female and those with mothers who were employed achieved higher scores on measures intellectual ability and/or adaptive functioning. Within the HEU group, no consistent associations were found between neurodevelopmental measures and HIV/ARV specific variables. HEU children demonstrated significantly lower scores on neurodevelopmental measures than HUU children during early childhood. Gaps in verbal intellectual abilities were identified with age, highlighting the importance of monitoring neurodevelopment in this population over time. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01