Reactivation-Dependent Amnesia for Object Recognition Memory Is Contingent on Hippocampal Theta-Gamma Coupling during Recall

Autor/inn/en	Gonzalez, Maria Carolina; Radiske, Andressa; Conde-Ocazionez, Sergio; Rossato, Janine I.; Bevilaqua, Lia R. M.; Cammarota, Martín
Titel	Reactivation-Dependent Amnesia for Object Recognition Memory Is Contingent on Hippocampal Theta-Gamma Coupling during Recall
Quelle	In: Learning & Memory, 29 (2022) 1, S.1-6 (6 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Cammarota, Martín)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Recall (Psychology); Brain Hemisphere Functions; Biochemistry; Neurological Impairments; Animals; Males; Novelty (Stimulus Dimension); Psychotherapy; Outcomes of Treatment + Suchen Sie Ihr Suchwort? Abberufung; Biochemie; Neurodegenerative Erkrankung; Animal; Tier; Tiere; Male; Männliches Geschlecht; Psychotherapie
Abstract	Hippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelty and memory processing. We found that, in adult male rats, ORM recall in the presence of a novel object, but not in the presence of a familiar one, triggers hippocampal theta-gamma coupling. Hippocampal theta-gamma coupling (hPAC) does not happen when ORM destabilization is prevented by blocking D1/D5 receptors, but artificial hPAC generation during recall in the presence of a familiar object enables the amnesic effect of reconsolidation inhibitors. Therefore, hPAC controls ORM destabilization, and its modulation could increase reconsolidation-based psychotherapy efficacy. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01