Sonification-Enhanced Lattice Model Animations for Teaching the Protein Folding Reaction

Autor/inn/en	Scaletti, Carla; Rickard, Meredith M.; Hebel, Kurt J.; Pogorelov, Taras V.; Taylor, Stephen A.; Gruebele, Martin
Titel	Sonification-Enhanced Lattice Model Animations for Teaching the Protein Folding Reaction
Quelle	In: Journal of Chemical Education, 99 (2022) 3, S.1220-1230 (11 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Rickard, Meredith M.) ORCID (Pogorelov, Taras V.) ORCID (Gruebele, Martin)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.1c00857
Schlagwörter	Animation; Models; Science Instruction; Chemistry; Undergraduate Students; Video Technology; Distance Education; Teaching Methods + Suchen Sie Ihr Suchwort? Analogiemodell; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Chemie; Distance study; Distance learning; Fernunterricht; Teaching method; Lehrmethode; Unterrichtsmethode
Abstract	The protein folding reaction is one of the most important chemical reactions in the human body. Yet, despite its importance, it is sometimes omitted from undergraduate courses due to the challenging nature of some of the underlying concepts. To help make key concepts of the protein folding reaction accessible to our undergraduate students, we implemented three, simplified 2D lattice models of various amino acid chains, and we used these models to generate sound-enhanced animations that allow students to see and hear the dynamics of protein folding in action. In spring of 2021, we used these videos in remote learning biophysics and music courses to introduce four key concepts of the folding reaction: solvation and hydrophobicity; energy and conformational entropy; funneled energy landscape; and frustration and traps. Our lattice model animations and sonifications helped provide insight into protein folding dynamics for undergraduate and graduate biophysical chemistry students, undergraduate musicians, and even authors who are experts in this field. We plan to incorporate these and additional animations, along with enhancements to the 2D lattice models, in our future courses. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01