Multistep Synthesis of a 3(2"H")-Furanone Featuring a Green Aldol Condensation

Autor/inn/en	Yousef, Abraham L.; Smith, Alexis G.
Titel	Multistep Synthesis of a 3(2"H")-Furanone Featuring a Green Aldol Condensation
Quelle	In: Journal of Chemical Education, 99 (2022) 2, S.946-951 (6 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Yousef, Abraham L.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.1c00634
Schlagwörter	Organic Chemistry; Laboratory Experiments; Science Experiments; Hands on Science; Science Instruction; College Science; Scientific Principles + Suchen Sie Ihr Suchwort? Organische Chemie; Laboratory work; Laborarbeit; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht
Abstract	A multistep synthesis of a novel arylidene 3(2"H")-furanone has been designed and optimized for the second-year organic laboratory. The three-step sequence consists of a nucleophilic substitution, intramolecular cyclization, and acid-catalyzed aldol condensation, and can be carried out within two 3 h laboratory periods. The final product is a crystalline solid that does not require purification and bears structural resemblance to natural products with medicinal properties. Reactions are performed at room temperature, and the aldol condensation takes place without the need for organic solvent, providing students hands-on experience with chemical transformations that illustrate green chemistry principles. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01