Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome

Autor/inn/en	Hall, Scott S.; Riley, Matthew J.; Weston, Robyn N.; Lepage, Jean-Francois; Hong, David S.; Jo, Booil; Hallmayer, Joachim; Reiss, Allan L.
Titel	Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 1, S.16-27 (12 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Hall, Scott S.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-04896-y
Schlagwörter	Genetics; Anxiety Disorders; Symptoms (Individual Disorders); Interpersonal Competence; Preadolescents; Females; Genetic Disorders; Congenital Impairments; Eye Movements; Behavior + Suchen Sie Ihr Suchwort? Humangenetik; Psychiatrische Symptomatik; Interpersonale Kompetenz; Pre-adolescence; Präadoleszenz; Weibliches Geschlecht; Augenbewegung
Abstract	Previous studies have suggested that girls with Turner syndrome (TS) exhibit symptoms of social anxiety during interactions with others. However, few studies have quantified these behaviors during naturalistic face-to-face social encounters. In this study, we coded observational markers of social anxiety in prepubertal girls with TS and age-matched controls during a 10-min social encounter with an unfamiliar examiner. Results showed that girls with TS exhibited significantly higher levels of gaze avoidance compared to controls. Impairments in social gaze were particularly increased in girls with a maternally retained X chromosome (Xm), suggesting a genomic imprinting effect. These data indicate that social gaze avoidance may be a critical behavioral marker for identifying early social dysfunction in young girls with TS. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01