Brief Report: Role of Parent-Reported Executive Functioning and Anxiety in Insistence on Sameness in Individuals with Germline "PTEN" Mutations

Autor/inn/en	Uljarevic, Mirko; Frazier, Thomas W.; Rached, Gaëlle; Busch, Robyn M.; Klaas, Patricia; Srivastava, Siddharth; Martinez-Agosto, Julian A.; Sahin, Mustafa; Eng, Charis; Hardan, Antonio Y.
Titel	Brief Report: Role of Parent-Reported Executive Functioning and Anxiety in Insistence on Sameness in Individuals with Germline "PTEN" Mutations
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 1, S.414-422 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-04881-5
Schlagwörter	Executive Function; Anxiety; Autism; Pervasive Developmental Disorders; Genetic Disorders; Predictor Variables; Cognitive Processes + Suchen Sie Ihr Suchwort? Angst; Autismus; Prädiktor; Cognitive process; Kognitiver Prozess
Abstract	This study aimed to characterize the relationship between insistence on sameness (IS), executive functioning (EF) and anxiety among individuals with "PTEN" mutations and individuals with macrocephalic ASD. The sample included 38 individuals with "PTEN" mutation and ASD diagnosis ("PTEN"-ASD; M[subscript age] = 8.93 years, SD[subscript age] = 4.75), 23 with "PTEN" mutation without ASD ("PTEN"-no ASD; M[subscript age] = 8.94 years; SD[subscript age] = 4.85) and 25 with ASD and macrocephaly but with no "PTEN" mutation (Macro-ASD; M[subscript age] = 11.99 years; SD[subscript age] = 5.15). The final model accounted for 45.7% of variance in IS, with Set-Shifting EF subdomain as a unique independent predictor (t = 4.12, p < 0.001). This investigation provides the first preliminary evidence for the EF-anxiety-IS interrelationship in individuals with "PTEN" mutations and with macrocephalic ASD. [This article was written on behalf of the Developmental Synaptopathies Consortium.] (As Provided).
Anmerkungen	Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01