Lifelong Reductions of PKM[zeta] in Ventral Hippocampus of Nonhuman Primates Exposed to Early-Life Adversity Due to Unpredictable Maternal Care

Autor/inn/en	Fulton, Sasha L.; Hsieh, Changchi; Atkin, Tobias; Norris, Ryan; Schoenfeld, Eric; Tsokas, Panayiotis; Fenton, André Antonio; Sacktor, Todd Charlton; Coplan, Jeremy D.
Titel	Lifelong Reductions of PKM[zeta] in Ventral Hippocampus of Nonhuman Primates Exposed to Early-Life Adversity Due to Unpredictable Maternal Care
Quelle	In: Learning & Memory, 28 (2021) 9, S.341-347 (7 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Fulton, Sasha L.) ORCID (Hsieh, Changchi) ORCID (Atkin, Tobias) ORCID (Schoenfeld, Eric) ORCID (Tsokas, Panayiotis) ORCID (Fenton, André Antonio) ORCID (Sacktor, Todd Charlton) ORCID (Coplan, Jeremy D.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Brain Hemisphere Functions; Animals; Memory; Biochemistry; Anxiety Disorders; Depression (Psychology); Disadvantaged Environment; Maintenance; Animal Behavior; Mothers; Emotional Response + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Gedächtnis; Biochemie; Tierverhalten; Mother; Mutter; Emotionales Verhalten
Abstract	Protein kinase M[zeta] (PKM[zeta]) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is a precursor to adult mood and anxiety disorders, in part, through persistent disruption of emotional memory throughout life. Here we subjected 10- to 16-wk-old male bonnet macaques to adversity by a maternal variable-foraging demand paradigm. We then examined PKM[zeta] expression in their ventral hippocampi as 7- to 12-yr-old adults. Quantitative immunohistochemistry reveals decreased PKM[zeta] in dentate gyrus, CA1, and subiculum of subjects who had experienced early-life adversity due to the unpredictability of maternal care. Adult animals with persistent decrements of PKM[zeta] in ventral hippocampus express timid rather than confrontational responses to a human intruder. Persistent down-regulation of PKM[zeta] in the ventral hippocampus might reduce the capacity for emotional memory maintenance and contribute to the long-lasting emotional effects of early-life adversity. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01