Females, but Not Males, Require Protein Degradation in the Hippocampus for Contextual Fear Memory Formation

Autor/inn/en	Martin, Kiley; Musaus, Madeline; Navabpour, Shaghayegh; Gustin, Aspen; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J.
Titel	Females, but Not Males, Require Protein Degradation in the Hippocampus for Contextual Fear Memory Formation
Quelle	In: Learning & Memory, 28 (2021) 8, S.248-253 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Fear; Memory; Gender Differences; Animals; Conditioning; Biochemistry; Brain Hemisphere Functions; Animal Behavior; Genetics + Suchen Sie Ihr Suchwort? Furcht; Gedächtnis; Geschlechterkonflikt; Animal; Tier; Tiere; Biochemie; Tierverhalten; Humangenetik
Abstract	Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin protein targeting in the dorsal hippocampus, the latter of which occurred at chaperones or RNA processing proteins. In vivo CRISPR--dCas9-mediated repression of protein degradation in the dorsal hippocampus impaired contextual fear memory in females, but not males. These results suggest a sex-specific role for protein degradation in the hippocampus during the consolidation of a contextual fear memory. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01