Association between Gray Matter Volume Variations and Energy Utilization in the Brain: Implications for Developmental Stuttering

Autor/inn/en	Boley, Nathaniel; Patil, Sanath; Garnett, Emily O.; Li, Hua; Chugani, Diane C.; Chang, Soo-Eun; Chow, Ho Ming
Titel	Association between Gray Matter Volume Variations and Energy Utilization in the Brain: Implications for Developmental Stuttering
Quelle	In: Journal of Speech, Language, and Hearing Research, 64 (2021) 6, S.2317-2324 (8 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Garnett, Emily O.) ORCID (Chugani, Diane C.) ORCID (Chang, Soo-Eun)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Stuttering; Brain Hemisphere Functions; Children; Energy; Metabolism; Correlation; Genetic Disorders; Michigan; Wechsler Preschool and Primary Scale of Intelligence; Peabody Picture Vocabulary Test; Goldman Fristoe Test of Articulation + Suchen Sie Ihr Suchwort? Stammer; Stottern; Child; Kind; Kinder; Energie; Stoffwechsel; Korrelation
Abstract	Purpose: The biological mechanisms underlying developmental stuttering remain unclear. In a previous investigation, we showed that there is significant spatial correspondence between regional gray matter structural anomalies and the expression of genes linked to energy metabolism. In the current study, we sought to further examine the relationship between structural anomalies in the brain in children with persistent stuttering and brain regional energy metabolism. Method: High-resolution structural MRI scans were acquired from 26 persistent stuttering and 44 typically developing children. Voxel-based morphometry was used to quantify the between-group gray matter volume (GMV) differences across the whole brain. Group differences in GMV were then compared with published values for the pattern of glucose metabolism measured via F18 fluorodeoxyglucose uptake in the brains of 29 healthy volunteers using positron emission tomography. Results: A significant positive correlation between GMV differences and F[superscript 18] fluorodeoxyglucose uptake was found in the left hemisphere ([rho] = 0.36, p < 0.01), where speech-motor and language processing are typically localized. No such correlation was observed in the right hemisphere ([rho] = 0.05, p = 0.70). Conclusions: Corroborating our previous gene expression studies, the results of the current study suggest a potential connection between energy metabolism and stuttering. Brain regions with high energy utilization may be particularly vulnerable to anatomical changes associated with stuttering. Such changes may be further exacerbated when there are sharp increases in brain energy utilization, which coincides with the developmental period of rapid speech/language acquisition and the onset of stuttering during childhood. (As Provided).
Anmerkungen	American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01