Literaturnachweis - Detailanzeige
| Autor/inn/en | Coyle, Robert; Farrell, Garrett; McFadden, Kim; Warren, Patricia |
|---|---|
| Titel | Exploring Excipients: Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods |
| Quelle | In: Journal of Chemical Education, 98 (2021) 8, S.2687-2692 (6 Seiten)Infoseite zur Zeitschrift
PDF als Volltext |
| Zusatzinformation | ORCID (Coyle, Robert) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0021-9584 |
| DOI | 10.1021/acs.jchemed.1c00233 |
| Schlagwörter | Chemistry; Science Instruction; Teaching Methods; Drug Therapy; Manufacturing; Cytology; Kinetics; Profiles; Undergraduate Students; Laboratory Experiments |
| Abstract | This practical is aimed at students who have been introduced to the tableting process, drug delivery systems, and dissolution. The student can design and manufacture a tablet investigating the effect of excipients and their role in tablet design and then generate a release profile of the tablet by using a dissolution apparatus, flow-through cell, and UV-vis kinetics. Economical alternatives to the otherwise expensive dies, presses, and dissolution apparatus required to conduct the practical are included so that this can be applied across a range of budgets. With the assumption that most undergraduate laboratories possess a 13 mm KBr die and hydraulic press, a 10 mm die and 6 mm die can cost in excess of €850, while homemade versions can be manufactured for less than €5. (As Provided). |
| Anmerkungen | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2024/1/01 |
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