Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Autor/inn/en	Zheng, Zhen; Zheng, Peng; Zou, Xiaobing
Titel	Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Quelle	In: Journal of Autism and Developmental Disorders, 51 (2021) 8, S.2569-2577 (9 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Zheng, Zhen)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-020-04710-1
Schlagwörter	Metabolism; Autism; Pervasive Developmental Disorders; Meta Analysis; Genetics; Neurological Impairments + Suchen Sie Ihr Suchwort? Stoffwechsel; Autismus; Meta-analysis; Metaanalyse; Humangenetik; Neurodegenerative Erkrankung
Abstract	The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41-1.53; p < 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01