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Autor/inn/en | Failla, Michelle D.; Schwartz, Kyle L.; Chaganti, Shikha; Cutting, Laurie E.; Landman, Bennett A.; Cascio, Carissa J. |
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Titel | Using Phecode Analysis to Characterize Co-Occurring Medical Conditions in Autism Spectrum Disorder |
Quelle | In: Autism: The International Journal of Research and Practice, 25 (2021) 3, S.800-811 (12 Seiten)
PDF als Volltext |
Zusatzinformation | ORCID (Failla, Michelle D.) ORCID (Landman, Bennett A.) |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 1362-3613 |
DOI | 10.1177/1362361320934561 |
Schlagwörter | Autism; Pervasive Developmental Disorders; Comorbidity; Neurological Impairments; Epilepsy; Sleep; Anxiety Disorders; Behavior Disorders; Hearing Impairments; Developmental Delays; Quality of Life |
Abstract | Individuals with autism spectrum disorder experience a significant number of co-occurring medical conditions, yet little is known about these conditions beyond prevalence. Using large-scale de-identified medical records, we can use a novel phecode-based tool to characterize co-occurring conditions in autism spectrum disorder. We hypothesized that individuals with autism spectrum disorder experience an increased burden of co-occurring conditions as measured by presence, frequency, and duration of visits related to co-occurring conditions. Secondarily, we hypothesized that age at first encounter for autism spectrum disorder (early, <5; late, >5) would be associated with different co-occurring conditions. The International Classification of Diseases, Ninth Revision, codes were extracted from a large anonymized electronic medical center database for 3097 individuals with autism spectrum disorder and 3097 matched controls. Co-occurring conditions were characterized using a novel tool (pyPheWAS) to examine presence, frequency, and duration of each condition. We identified several categories of co-occurring conditions in autism spectrum disorder: neurological (convulsions, sleep disorders); psychiatric (anxiety disorders, adjustment/conduct disorders), as well as constipation, hearing loss, and developmental delays. Our work confirms individuals with autism spectrum disorder are under a significant medical burden, with increased duration and frequency of visits associated with co-occurring conditions. Adequate management of these conditions could improve quality of life for individuals with autism spectrum disorder. (As Provided). |
Anmerkungen | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: http://sagepub.com |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2024/1/01 |