Antiepileptic Drugs, Occurrence of Seizures and Effect of Co-Administration of Potential Seizure Threshold-Lowering Psychotropic Drugs in Adults with Intellectual Disability Who Have Epilepsy

Autor/inn/en	Monaghan, Rosemary; O'Dwyer, Máire; Luus, Retha; Mulryan, Niamh; McCallion, Philip; McCarron, Mary; Henman, Martin C.
Titel	Antiepileptic Drugs, Occurrence of Seizures and Effect of Co-Administration of Potential Seizure Threshold-Lowering Psychotropic Drugs in Adults with Intellectual Disability Who Have Epilepsy
Quelle	In: Journal of Applied Research in Intellectual Disabilities, 34 (2021) 3, S.818-829 (12 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Monaghan, Rosemary) ORCID (O'Dwyer, Máire) ORCID (Mulryan, Niamh) ORCID (McCallion, Philip)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1360-2322
DOI	10.1111/jar.12857
Schlagwörter	Drug Therapy; Seizures; Epilepsy; Intellectual Disability; Program Effectiveness; Risk Management; Incidence; Adults + Suchen Sie Ihr Suchwort? Anfallsleiden; Epilepsie; Intellect; Disability; Disabilities; Verstand; Behinderung; Risikomanagement; Vorkommen
Abstract	Background: This study explored antiepileptic drug use, frequency of seizures, and the effect of psychotropic drugs with the potential to lower the seizure threshold in persons diagnosed with epilepsy and intellectual disability. Methods: Data for this study were drawn from Wave 3 of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA). Psychotropic drugs were categorised for potential seizure threshold-lowering risk (low, moderate, high). Binary logistic regression was performed to identify factors associated with seizure frequency. Results: Epilepsy prevalence was 35.8% (n = 196), of which 57.7% reported a mental health condition. Participants with seizure data classified as taking at least one moderate-/high-risk medication were significantly less likely to experience a seizure compared to participants taking no potential seizure threshold-lowering medication. Conclusions: Psychotropic drugs recommended to be avoided or used with caution did not provoke increased seizure frequency in this cohort. (As Provided).
Anmerkungen	Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01