Analysis of Protonation Equilibria of Amino Acids in Aqueous Solutions Using Microsoft Excel

Autor/inn/en	Šarac, Bojan; Hadži, San
Titel	Analysis of Protonation Equilibria of Amino Acids in Aqueous Solutions Using Microsoft Excel
Quelle	In: Journal of Chemical Education, 98 (2021) 3, (7 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Šarac, Bojan)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
Schlagwörter	Science Instruction; College Science; Undergraduate Study; Spreadsheets; Educational Technology; Technology Uses in Education; Scientific Concepts; Concept Formation; Computer Software; Biochemistry; Science Experiments; Laboratory Experiments + Suchen Sie Ihr Suchwort? Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Grundstudium; Spread sheet; Spredsheets; Spreadsheet; Tabellenkalkulation; Unterrichtsmedien; Technology enhanced learning; Technology aided learning; Technologieunterstütztes Lernen; Concept learning; Begriffsbildung; Biochemie; Laboratory work; Laborarbeit
Abstract	A Microsoft Excel workbook has been developed to simplify the quantitative analysis of experimentally measured titration curves for diprotic and triprotic amino acids such as glycine, arginine, histidine, and glutamate. Students perform the titration, enter the data into the worksheet, and manually adjust the resulting pK[subscript a] values to achieve the closest agreement between the experimental and calculated titration curves. At the same time, the students can observe changes in the speciation diagram that illustrates the transitions of differently protonated molecular species during the titration. Through a combination of graphical visualization and analysis, supported by computer software, students learn the most important aspects of the protonation equilibria of amino acid solutions. The knowledge gained can serve as the basis for understanding the behavior of more complex polyprotic acids in aqueous solution and the pK[subscript a] values of amino acid residues in proteins. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01