Postreactivation Mifepristone Impairs Generalization of Strongly Conditioned Contextual Fear Memories

Autor/inn/en	Flavell, Charlotte R.; Gascoyne, Rebecca M.; Lee, Jonathan L. C.
Titel	Postreactivation Mifepristone Impairs Generalization of Strongly Conditioned Contextual Fear Memories
Quelle	In: Learning & Memory, 27 (2020) 12, S.483-487 (5 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Lee, Jonathan L. C.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.052167.120
Schlagwörter	Fear; Drug Use; Memory; Age Differences; Conditioning; Animals; Males; Context Effect; Generalization + Suchen Sie Ihr Suchwort? Furcht; Drug consumption; Substance abuse; Drogenkonsum; Gedächtnis; Age; Difference; Age difference; Altersunterschied; Animal; Tier; Tiere; Male; Männliches Geschlecht
Abstract	The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear memory destabilization to facilitate mifepristone-induced reconsolidation impairment. Here, we applied nefiratecam and mifepristone to strongly conditioned, 1-wk-old contextual fear memories in male rats. Unexpectedly, the combined treatment did not result in impairment of contextual fear expression. However, mifepristone did reduce freezing to a novel context. These observations suggest that strong and established contextual fear memories do undergo destabilization without the need for pharmacological facilitation, and that impairments in strong context fear memory reconsolidation can manifest as a reduction in generalization. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01