Association between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder

Autor/inn/en	Li, Yan; Qiu, Shuang; Zhong, Weijing; Li, Yong; Liu, Yunkai; Cheng, Yi; Liu, Yawen
Titel	Association between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 50 (2020) 10, S.3800-3809 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-020-04417-3
Schlagwörter	Autism; Pervasive Developmental Disorders; Genetic Disorders; At Risk Persons; Genetics; Foreign Countries; China + Suchen Sie Ihr Suchwort? Autismus; Risikogruppe; Humangenetik; Ausland
Abstract	Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in "DCC" on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in "DCC"; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in "DCC" may be implicated in ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01