Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder

Autor/inn/en	Constable, Paul A.; Ritvo, Edward R.; Ritvo, Ariella R.; Lee, Irene O.; McNair, Morgan L.; Stahl, Dylan; Sowden, Jane; Quinn, Stephen; Skuse, David H.; Thompson, Dorothy A.; McPartland, James C.
Titel	Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 50 (2020) 8, S.2874-2885 (12 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Constable, Paul A.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-020-04396-5
Schlagwörter	Vision; Screening Tests; Autism; Pervasive Developmental Disorders; Neurology; Physiology; Brain; Cognitive Development + Suchen Sie Ihr Suchwort? Screening-Verfahren; Autismus; Neurologie; Physiologie; Gehirn; Kognitive Entwicklung
Abstract	Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m[superscript -2] white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < 0.001) and slower b-wave peak times (p < 0.001). Photopic hill models showed the peaks of the component Gaussian (p = 0.035) and logistic functions (p = 0.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01