Biochemical Screening of Intellectually Disabled and Healthy Children in Punjab, Pakistan: Differences in Liver Function Test and Lipid Profiles

Autor/inn/en	Wasim, Muhammad; Khan, Haq Nawaz; Ayesha, Hina; Awan, Fazli Rabbi
Titel	Biochemical Screening of Intellectually Disabled and Healthy Children in Punjab, Pakistan: Differences in Liver Function Test and Lipid Profiles
Quelle	In: International Journal of Developmental Disabilities, 66 (2020) 3, S.190-195 (6 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Wasim, Muhammad) ORCID (Awan, Fazli Rabbi)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	2047-3869
DOI	10.1080/20473869.2018.1533084
Schlagwörter	Biochemistry; Screening Tests; Foreign Countries; Metabolism; Genetic Disorders; Clinical Diagnosis; Intellectual Disability; Comparative Analysis; Case Studies; Diseases; Profiles; Preschool Children; Young Adults; Adolescents; Pakistan + Suchen Sie Ihr Suchwort? Biochemie; Screening-Verfahren; Ausland; Stoffwechsel; Intellect; Disability; Disabilities; Verstand; Behinderung; Case study; Fallstudie; Case Study; Disease; Krankheit; Charakterisierung; Profilanalyse; Pre-school age; Preschool age; Child; Children; Pre-school education; Preschool education; Vorschulalter; Kind; Kinder; Vorschulkind; Vorschulkinder; Vorschulerziehung; Vorschule; Young adult; Junger Erwachsener; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher
Abstract	Objectives: Inborn errors of metabolism (IEMs) are rare genetic disorders. Generally, IEMs are untreatable; however, some IEMs causing intellectual disability are potentially treatable if diagnosed earlier. In this study, levels of some clinically important biochemical parameters in intellectually disabled children suspected for IEMs were tested to see their association with intellectual disability, which could be helpful in preliminary screening. Methods: This comparative cross-sectional observational study was carried out from 2014 to 2017. Blood samples from 800 boys and girls (aged 4-24 years) were collected, of which 391 were healthy (IQ >90) and 409 were intellectually disabled (IQ <70) children with unknown cause. Clinically important (Liver and kidney enzymes etc.) biochemical parameters were analyzed in sera samples using commercial kits on semi-automated clinical chemistry analyzer. Results: Serum analysis showed the levels of ALP (p < 0.00001), ASAT (p = 0.001), ALAT (p = 0.016), albumin (p < 0.001), uric acid (p < 0.001), cholesterol (p < 0.001), triglycerides (p < 0.001), and hemoglobin (p = 0.005) were significantly different between healthy and intellectually disabled children. Conclusion: Changes in the liver function test and lipid profile parameters were significantly different in children with intellectual disability; however, it requires further detailed analysis for complete characterization of these diseases. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01