Going Green in Process Chemistry: Optimizing an Asymmetric Oxidation Reaction to Synthesize the Antiulcer Drug Esomeprazole

Autor/inn/en	McAllister, Graeme D.; Parsons, Andrew F.
Titel	Going Green in Process Chemistry: Optimizing an Asymmetric Oxidation Reaction to Synthesize the Antiulcer Drug Esomeprazole
Quelle	In: Journal of Chemical Education, 96 (2019) 11, S.2617-2621 (5 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Parsons, Andrew F.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
Schlagwörter	Science Instruction; Organic Chemistry; Science Laboratories; Drug Therapy; Inquiry; Student Attitudes; Program Effectiveness; Teamwork; Interpersonal Communication; Science Experiments; Research Skills + Suchen Sie Ihr Suchwort? Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Organische Chemie; Schülerverhalten; Interpersonale Kommunikation; Forschungsleistung
Abstract	Sustainable practices in process chemistry are highlighted by a novel, 9 week team project of 8-12 students, in collaboration with AstraZeneca chemists, in an organic chemistry laboratory. Students synthesize the antiulcer medicine esomeprazole, which involves the asymmetric oxidation of pyrmetazole. To provide insight into the modern process chemistry industry, they propose environmentally friendly modifications to the asymmetric oxidation. Students first synthesize pyrmetazole and then follow a standard oxidation procedure and carry out modified, greener reactions of their choice. They investigate how a change in reaction conditions affects both the yield and enantioselectivity of esomeprazole. Positive student feedback was received and student postlab reports were analyzed over a 4 year period (2015-2018). Results consistently showed that the project provided students with the key tools to develop greener syntheses. This contextual approach not only offers the opportunity to develop valuable communication and team-working skills, but it also gives students creative input into their experimental work. It teaches the important research skills involved in sustainable process chemistry, from reproducing and modifying a literature procedure to identifying green metrics. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01