Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder

Autor/inn/en	Kahathuduwa, Chanaka N.; West, Blake; Mastergeorge, Ann
Titel	Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 12, S.4751-4760 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-04187-7
Schlagwörter	Obesity; Brain Hemisphere Functions; Autism; Pervasive Developmental Disorders; Risk; Physiology; Diagnostic Tests; Profiles; Attribution Theory; Neurology; Correlation + Suchen Sie Ihr Suchwort? Adipositas; Autismus; Risiko; Physiologie; Diagnostic test; Diagnostischer Test; Charakterisierung; Profilanalyse; Neurologie; Korrelation
Abstract	Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01