Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life

Autor/inn/en	Schroder, Carmen M.; Malow, Beth A.; Maras, Athanasios; Melmed, Raun D.; Findling, Robert L.; Breddy, John; Nir, Tali; Shahmoon, Shiri; Zisapel, Nava; Gringras, Paul
Titel	Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 8, S.3218-3230 (13 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-04046-5
Schlagwörter	Autism; Pervasive Developmental Disorders; Genetic Disorders; Sleep; Drug Therapy; Child Behavior; Quality of Life; Caregivers; Behavior Modification; Behavior Problems; Strengths and Difficulties Questionnaire + Suchen Sie Ihr Suchwort? Autismus; Schlaf; Lebensqualität; Caregiver; Carer; Betreuungsperson; Pfleger; Behaviour modification; Verhaltensänderung
Abstract	A randomized, 13-weeks, placebo-controlled double-blind study in 125 subjects aged 2-17.5 years with Autism Spectrum Disorder or Smith-Magenis syndrome and insomnia demonstrated efficacy and safety of easily-swallowed prolonged-release melatonin mini-tablets (PedPRM; 2-5 mg) in improving sleep duration and onset. Treatment effects on child behavior and caregiver's quality of life were evaluated. PedPRM treatment resulted in significant improvement in externalizing but not internalizing behavior (Strengths and Difficulties questionnaire; SDQ) compared to placebo (p = 0.021) with clinically-relevant improvements in 53.7% of PedPRM-treated versus 27.6% of placebo-treated subjects (p = 0.008). Caregivers' quality of life also improved with PedPRM versus placebo (p = 0.010) and correlated with the change in total SDQ (p = 0.0005). PedPRM alleviates insomnia-related difficulties, particularly externalizing behavior in the children, subsequently improving caregivers' quality of life. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01