Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder

Autor/inn/en	Huberman Samuel, Maayan; Meiri, Gal; Dinstein, Ilan; Flusser, Hagit; Michaelovski, Analiya; Bashiri, Asher; Menashe, Idan
Titel	Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 8, S.3127-3135 (9 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Menashe, Idan)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-04034-9
Schlagwörter	Anesthesiology; Birth; Autism; Pervasive Developmental Disorders; Risk; Developmental Delays + Suchen Sie Ihr Suchwort? Anästhesie; Geburt; Autismus; Risiko; Entwicklungsverzögerung
Abstract	Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026-2.302, and aOR = 1.692; 95% CI 1.057-2.709, p[subscript diff] = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01