Literaturnachweis - Detailanzeige
| Autor/inn/en | da Silva, Rodrigo Sens; Borges, Endler Marcel |
|---|---|
| Titel | Quantitative Analysis Using a Flatbed Scanner: Aspirin Quantification in Pharmaceutical Tablets |
| Quelle | In: Journal of Chemical Education, 96 (2019) 7, S.1519-1526 (8 Seiten)Infoseite zur Zeitschrift
PDF als Volltext |
| Zusatzinformation | ORCID (Borges, Endler Marcel) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0021-9584 |
| Schlagwörter | Spreadsheets; Drug Therapy; Light; Chemistry; Accuracy; Science Experiments; Cost Effectiveness; Teaching Methods; Laboratory Experiments; Undergraduate Students; Spectroscopy; Hands on Science; Pharmacology |
| Abstract | Here, students determine aspirin (acetylsalicylic acid) mass in pharmaceutical tablets using a colorimetric method. Aspirin, salicylate, and salicylic acid do not absorb visible light. Thus, in alkaline medium, acetylsalicylic acid was hydrolyzed to salicylate; then, it was reacted with an acidic Fe(III) solution, and a violet complex was formed. Quantitative analysis was carried out using absorbance measured at 535 nm (standard method) and digital images obtained with a flatbed scanner (proposed method). Results obtained with both methods were compared using an F-test and a t-test; both methods had shown equivalent accuracy and precision at the 95% confidence level. In addition, one-way ANOVA showed that aspirin masses found by five student groups using both methods are equivalent at the 95% confidence level. In the proposed method, samples were placed in a 96 microwell plate, and RGB values were extracted automatically from all wells in less than 5 min using ImageJ's plugin "ReadPlate"; data obtained were organized using a spreadsheet to determine aspirin mass in pharmaceutical tablets, recovery, and percent error. Our goal was to design a portable, cost-effective, and user-friendly platform and to develop an experimental methodology that can easily be applied to any research and education laboratory using just a flatbed scanner. (As Provided). |
| Anmerkungen | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2020/1/01 |
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