EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study

Autor/inn/en	Nicotera, Antonio Gennaro; Hagerman, Randi Jenssen; Catania, Maria Vincenza; Buono, Serafino; Di Nuovo, Santo; Liprino, Elisa Maria; Stracuzzi, Emanuela; Giusto, Stefania; Di Vita, Giuseppina; Musumeci, Sebastiano Antonino
Titel	EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 6, S.2337-2347 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-03908-2
Schlagwörter	Autism; Pervasive Developmental Disorders; Neurological Impairments; Diagnostic Tests; Severity (of Disability); Hyperactivity; Self Control; Emotional Response; Aggression; Behavior Problems; Psychomotor Skills; Intellectual Disability; Language Impairments; Self Destructive Behavior + Suchen Sie Ihr Suchwort? Autismus; Neurodegenerative Erkrankung; Diagnostic test; Diagnostischer Test; Schweregrad; Hyperaktivität; Selbstbeherrschung; Emotionales Verhalten; Psychomotorische Aktivität; Intellect; Disability; Disabilities; Verstand; Behinderung; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Self destrucive behaviour; Selbstzerstörung
Abstract	To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impairment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01