Whole Blood Serotonin Levels and Platelet 5-HT[subscript 2A] Binding in Autism Spectrum Disorder

Autor/inn/en	Aaron, Elizabeth; Montgomery, Alicia; Ren, Xinguo; Guter, Stephen; Anderson, George; Carneiro, Ana M. D.; Jacob, Suma; Mosconi, Matthew; Pandey, Ghanshyam N.; Cook, Edwin; Veenstra-VanderWeele, Jeremy
Titel	Whole Blood Serotonin Levels and Platelet 5-HT[subscript 2A] Binding in Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 6, S.2417-2425 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-03989-z
Schlagwörter	Autism; Pervasive Developmental Disorders; Physiology; Metabolism; Correlation + Suchen Sie Ihr Suchwort? Autismus; Physiologie; Stoffwechsel; Korrelation
Abstract	Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT[subscript 2A] binding has been reported in ASD. WB5-HT levels and platelet 5-HT[subscript 2A] specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT[subscript 2A] specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT[subscript 2A] binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01