A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children

Autor/inn/en	Mazahery, Hajar; Conlon, Cathryn A.; Beck, Kathryn L.; Mugridge, Owen; Kruger, Marlena C.; Stonehouse, Welma; Camargo, Carlos A.; Meyer, Barbara J.; Tsang, Bobby; Jones, Beatrix; von Hurst, Pamela R.
Titel	A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 5, S.1778-1794 (17 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Mazahery, Hajar)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-018-3860-y
Schlagwörter	Symptoms (Individual Disorders); Intervention; Outcomes of Treatment; Nutrition; Sensory Integration; Autism; Pervasive Developmental Disorders; Toddlers; Children; Young Children; Drug Therapy; Biochemistry; Interpersonal Competence; Communication Skills; Psychomotor Skills + Suchen Sie Ihr Suchwort? Psychiatrische Symptomatik; Ernährung; Sensorische Integration; Autismus; Infant; Infants; Toddler; Kleinkind; Child; Kind; Kinder; Frühe Kindheit; Biochemie; Interpersonale Kompetenz; Kommunikationsstil; Psychomotorische Aktivität
Abstract	We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5-8.0 years) received daily 2000 IU vitamin D[subscript 3], 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01