Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

Autor/inn/en	Raghavan, Ramkripa; Fallin, M. Daniele; Hong, Xiumei; Wang, Guoying; Ji, Yuelong; Stuart, Elizabeth A.; Paige, David; Wang, Xiaobin
Titel	Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 1, S.173-184 (12 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Raghavan, Ramkripa)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-018-3688-5
Schlagwörter	Autism; Pervasive Developmental Disorders; Risk; Physiology; Biochemistry; Physicians; Clinical Diagnosis; Correlation; Genetics; Birth + Suchen Sie Ihr Suchwort? Autismus; Risiko; Physiologie; Biochemie; Physician; Doctor; Arzt; Korrelation; Humangenetik; Geburt
Abstract	Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01