Process Analytical Technology for Online Monitoring of Organic Reactions by Mass Spectrometry and UV-Vis Spectroscopy

Autor/inn/en	Fedick, Patrick W.; Schrader, Robert L.; Ayrton, Stephen T.; Pulliam, Christopher J.; Cooks, R. Graham
Titel	Process Analytical Technology for Online Monitoring of Organic Reactions by Mass Spectrometry and UV-Vis Spectroscopy
Quelle	In: Journal of Chemical Education, 96 (2019) 1, S.124-131 (8 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Fedick, Patrick W.) ORCID (Cooks, R. Graham)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.8b00725
Schlagwörter	Science Education; Spectroscopy; Laboratory Equipment; Science Laboratories; Scientific Concepts; Hands on Science; Organic Chemistry; College Science; Undergraduate Study + Suchen Sie Ihr Suchwort? Naturwissenschaftliche Bildung; Spektroskopie; Laborausstattung; Organische Chemie; Grundstudium
Abstract	Process analytical technologies (PATs) are used in the pharmaceutical and other industries to monitor chemical processes in real-time with analytical instrumentation. Each PAT analyzer brings its own advantages and disadvantages to the process, and multiplexing PAT analyzers can be advantageous as they can provide confirmatory measurements and increase the overall confidence of the analysis. In a pedagogical setting, online reaction monitoring enables the instructor to explain the fundamentals of instrumental techniques while highlighting pertinent real world applications. Here we present a teaching laboratory exercise in which students monitor an amide bond formation reaction by flow UV-vis spectroscopy and by mass spectrometric analysis. The coupling of these two specific instruments allows students to investigate two instruments in one laboratory exercise, to explore the fundamentals behind each, and to contemplate the advantages and disadvantages of these instrumental methods. The coupling of the two instruments was aided by 3D printing which allowed students to explore how rapid prototyping can enable the development of innovative procedures. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01