Using Classical EDTA Titrations to Measure Calcium and Magnesium in Intravenous Fluid Bags

Autor/inn/en	Kimaru, Irene W.; Corigliano, Anthony T.; Zhao, Fang
Titel	Using Classical EDTA Titrations to Measure Calcium and Magnesium in Intravenous Fluid Bags
Quelle	In: Journal of Chemical Education, 95 (2018) 12, S.2238-2242 (5 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Kimaru, Irene W.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.8b00412
Schlagwörter	Chemistry; Science Instruction; Interdisciplinary Approach; Transformative Learning; Learning Experience; Pharmaceutical Education; Undergraduate Students; Outcomes of Education; Drug Therapy; Pharmacy; Biochemistry; Laboratory Experiments; Quality Control; Course Descriptions + Suchen Sie Ihr Suchwort? Chemie; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Fächerübergreifender Unterricht; Fächerverbindender Unterricht; Interdisziplinarität; Pädagogische Transformation; Lernerfahrung; Lernleistung; Schulerfolg; Apotheke; Biochemie; Laboratory work; Laborarbeit; Qualitätskontrolle; Kursstrukturplan
Abstract	Potency assays of pharmaceutical products are designed to measure the amount of an active ingredient in a sample. They are important quality control tools for all medications, including intravenous (IV) admixture fluid bags which are commonly prepared by pharmacists in healthcare facilities via extemporaneous compounding. An interdisciplinary laboratory module was created by combining the learning outcomes of a pharmacy compounding course with the classic undergraduate chemistry quantitative analysis course. The pharmacy students prepared the IV bags of calcium gluconate or magnesium sulfate in isotonic saline vehicle based on given prescriptions. The analytical chemistry students applied United States Pharmacopeia complexometric titration methods to determine the concentration of calcium or magnesium in the IV fluid and convert it to mass for each bag. The analytical results allowed the pharmacy students to confirm whether their IV bags met the passing criteria for the labeled claimed mass. This transformative learning experience provides an interesting real-life application for a quantitative analysis laboratory course and highlights the importance of quality control in the pharmacy compounding course. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01