Literaturnachweis - Detailanzeige
| Autor/inn/en | Millard, Julie T.; Passang, Tenzin; Ye, Jiayu; Kline, Gabriel M.; Beachy, Tina M.; Hepburn, Victoria L.; Klinkerch, Edmund J. |
|---|---|
| Titel | Genotype and Phenotype of Caffeine Metabolism: A Biochemistry Laboratory Experiment |
| Quelle | In: Journal of Chemical Education, 95 (2018) 10, S.1856-1860 (5 Seiten)Infoseite zur Zeitschrift
PDF als Volltext |
| Zusatzinformation | ORCID (Millard, Julie T.) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0021-9584 |
| DOI | 10.1021/acs.jchemed.8b00318 |
| Schlagwörter | Science Instruction; College Science; Undergraduate Study; Biochemistry; Science Laboratories; Genetics; Metabolism; Drug Use; Science Experiments; Laboratory Experiments |
| Abstract | An experiment for the upper-division undergraduate biochemistry laboratory is described in which students investigate the influence of genetic variations of cytochrome P450 1A2 on drug metabolism, using caffeine as a model compound. Saliva samples from human subjects are characterized for a single-nucleotide polymorphism in the CYP1A2 gene (genotyping) and for the rate of caffeine clearance (phenotyping). This experiment has clinical significance in the area of personalized medicine. (As Provided). |
| Anmerkungen | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2020/1/01 |
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