Contextual Fear Conditioning in Zebrafish

Autor/inn/en	Kenney, Justin W.; Scott, Ian C.; Josselyn, Sheena A.; Frankland, Paul W.
Titel	Contextual Fear Conditioning in Zebrafish
Quelle	In: Learning & Memory, 24 (2017) 10, S.516-523 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045690.117
Schlagwörter	Context Effect; Fear; Conditioning; Animals; Stimuli; Negative Reinforcement; Adults; Learning Processes; Genetics; Memory; Experiments + Suchen Sie Ihr Suchwort? Furcht; Animal; Tier; Tiere; Anreizsystem; Negative Verstärkung; Learning process; Lernprozess; Humangenetik; Gedächtnis; Erprobung
Abstract	Zebrafish are a genetically tractable vertebrate that hold considerable promise for elucidating the molecular basis of behavior. Although numerous recent advances have been made in the ability to precisely manipulate the zebrafish genome, much less is known about many aspects of learning and memory in adult fish. Here, we describe the development of a contextual fear conditioning paradigm using an electric shock as the aversive stimulus. We find that contextual fear conditioning is modulated by shock intensity, prevented by an established amnestic agent (MK-801), lasts at least 14 d, and exhibits extinction. Furthermore, fish of various background strains (AB, Tu, and TL) are able to acquire fear conditioning, but differ in fear extinction rates. Taken together, we find that contextual fear conditioning in zebrafish shares many similarities with the widely used contextual fear conditioning paradigm in rodents. Combined with the amenability of genetic manipulation in zebrafish, we anticipate that our paradigm will prove to be a useful complementary system in which to examine the molecular basis of vertebrate learning and memory. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01