Developmental Pathway Genes and Neural Plasticity Underlying Emotional Learning and Stress-Related Disorders

Autor/inn/en	Maheau, Marissa E.; Ressler, Kerry J.
Titel	Developmental Pathway Genes and Neural Plasticity Underlying Emotional Learning and Stress-Related Disorders
Quelle	In: Learning & Memory, 24 (2017) 9, S.492-501 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.044271.116
Schlagwörter	Genetics; Emotional Development; Stress Variables; Anxiety Disorders; Psychiatry; Neurology + Suchen Sie Ihr Suchwort? Humangenetik; Gefühlsbildung; Psychiatrie; Neurologie
Abstract	The manipulation of neural plasticity as a means of intervening in the onset and progression of stress-related disorders retains its appeal for many researchers, despite our limited success in translating such interventions from the laboratory to the clinic. Given the challenges of identifying individual genetic variants that confer increased risk for illnesses like depression and post-traumatic stress disorder, some have turned their attention instead to focusing on so-called "master regulators" of plasticity that may provide a means of controlling these potentially impaired processes in psychiatric illnesses. The mammalian homolog of "Tailless" (TLX), Wnt, and the homeoprotein Otx2 have all been proposed to constitute master regulators of different forms of plasticity which have, in turn, each been implicated in learning and stress-related disorders. In the present review, we provide an overview of the changing distribution of these genes and their roles both during development and in the adult brain. We further discuss how their distinct expression profiles provide clues as to their function, and may inform their suitability as candidate drug targets in the treatment of psychiatric disorders. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01