Individual Differences in Fear Extinction and Anxiety-Like Behavior

Autor/inn/en	King, Gabrielle; Scott, Elliot; Graham, Bronwyn M.; Richardson, Rick
Titel	Individual Differences in Fear Extinction and Anxiety-Like Behavior
Quelle	In: Learning & Memory, 24 (2017) 5, S.182-190 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045021.117
Schlagwörter	Inhibition; Fear; Anxiety; Individual Differences; Stress Variables; Animals; Behavior; Risk; Anxiety Disorders + Suchen Sie Ihr Suchwort? Hemmung; Furcht; Angst; Individueller Unterschied; Animal; Tier; Tiere; Risiko
Abstract	There is growing appreciation for the substantial individual differences in the acquisition and inhibition of aversive associations, and the insights this might give into identifying individuals particularly vulnerable to stress and psychopathology. We examined whether animals that differed in rate of extinction (i.e., Fast versus Slow) were different in their response to an acute stress in adulthood or following a chronic stress that occurred either early or later in life. We found that Slow Extinguishers had significantly poorer extinction retention than Fast Extinguishers, but an acute stressor did not differentially affect anxiety-like behavior in the two groups. Further, while exposure to chronic stress in adulthood did not impact on the extinction phenotypes or anxiety-like behavior, exposure to chronic stress early in life affected both extinction retention and anxiety-like behavior. These findings have implications for the development of a more nuanced approach to identifying those most at risk of anxiety disorders. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01