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| Autor/inn/en | Hernandez, John S.; Wainwright, Marcy L.; Mozzachiodi, Riccardo |
|---|---|
| Titel | Long-Term Sensitization Training in "Aplysia" Decreases the Excitability of a Decision-Making Neuron through a Sodium-Dependent Mechanism |
| Quelle | In: Learning & Memory, 24 (2017) 6, S.257-261 (5 Seiten)
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| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 1072-0502 |
| DOI | 10.1101/lm.044883.116 |
| Schlagwörter | Decision Making; Brain Hemisphere Functions; Animals; Cytology; Food; Diagnostic Tests; Drug Use; Training; Comparative Analysis; Cognitive Processes |
| Abstract | In "Aplysia," long-term sensitization (LTS) occurs concurrently with a suppression of feeding. At the cellular level, the suppression of feeding is accompanied by decreased excitability of decision-making neuron B51. We examined the contribution of voltage-gated Na[superscript +] and K[superscript +] channels to B51 decreased excitability. In a pharmacologically isolated Na[superscript +] channels environment, LTS training significantly increased B51 firing threshold, compared with untrained controls. Conversely, in a pharmacologically isolated K[superscript +] channels environment, no differences were observed between trained and untrained animals in either amplitude or area of B51 K[superscript +]-dependent depolarizations. These findings suggest that Na[superscript +] channels contribute to the decrease in B51 excitability induced by LTS training. (As Provided). |
| Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2020/1/01 |
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