Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study

Autor/inn/en	Losh, Molly; Martin, Gary E.; Lee, Michelle; Klusek, Jessica; Sideris, John; Barron, Sheila; Wassink, Thomas
Titel	Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study
Quelle	In: Journal of Autism and Developmental Disorders, 47 (2017) 3, S.834-845 (12 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Losh, Molly)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-016-2996-x
Schlagwörter	Genetics; Autism; Pervasive Developmental Disorders; Parents; Academic Achievement; Control Groups; Experimental Groups; Language Arts; Reading; Mathematics; Elementary Secondary Education; Predictor Variables; Severity (of Disability); Symptoms (Individual Disorders); Longitudinal Studies; Intelligence Quotient; Children; Intelligence Tests; Language Skills; Rating Scales; Personality Traits; Diagnostic Tests; Observation; Hierarchical Linear Modeling; Achievement Tests; Standardized Tests; Semi Structured Interviews; Iowa; Wechsler Intelligence Scale for Children; Autism Diagnostic Observation Schedule; Iowa Tests of Basic Skills; Iowa Tests of Educational Development + Suchen Sie Ihr Suchwort? Humangenetik; Autismus; Eltern; Schulleistung; Sprachkultur; Leseprozess; Lesen; Mathematik; Prädiktor; Schweregrad; Psychiatrische Symptomatik; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Intelligenzquotient; Child; Kind; Kinder; Intelligence test; Intelligenztest; Language skill; Sprachkompetenz; Rating-Skala; Individual characteristics; Personality characteristic; Persönlichkeitsmerkmal; Diagnostic test; Diagnostischer Test; Beobachtung; Achievement test; Achievement; Testing; Test; Tests; Leistungsbeurteilung; Leistungsüberprüfung; Leistung; Testdurchführung; Testen; Standadised tests; Standardisierter Test
Abstract	Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01