Mothers of Children with Autism Have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child

Autor/inn/en	Fairthorne, Jennifer C.; de Klerk, Nicholas H.; Leonard, Helen M.; Whitehouse, Andrew J. O.
Titel	Mothers of Children with Autism Have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child
Quelle	In: Journal of Autism and Developmental Disorders, 46 (2016) 9, S.3106-3114 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-016-2847-9
Schlagwörter	Foreign Countries; Autism; Pervasive Developmental Disorders; Intellectual Disability; Mothers; Children; Cancer; Hospitals; Medical Services; Regression (Statistics); Risk; Genetics; Australia + Suchen Sie Ihr Suchwort? Ausland; Autismus; Intellect; Disability; Disabilities; Verstand; Behinderung; Mother; Mutter; Child; Kind; Kinder; Carcinoma; Karzinom; Krebs (med); Krebserkrankung; Krankengymnast; Krankenhaus; Arzt; Regression; Regressionsanalyse; Risiko; Humangenetik; Australien
Abstract	Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with strong genetic components. Increasingly, research attention has focused on whether genetic factors conveying susceptibility for these conditions, also influence the risk of other health conditions, such as cancer. We examined the occurrence of hospital admissions and treatment/services for cancer in mothers of children with ASD with or without ID compared with other mothers. After linking Western Australian administrative health databases, we used Cox regression to estimate the hazard ratios (HRs) of any hospitalisations and treatment/services for cancer in these groups of mothers. Mothers of children with ASD without ID had greater risk of admissions for cancer (HR 1.29 [95% CI 1.1, 1.7]), and for treatment/services in particular (HR 1.41 [95% CI 1.0, 2.0]), than mothers of children with no ASD/ID, while mothers of children with ASD with ID were no more likely to have a cancer-related hospital admission than other mothers. Mothers of children with autism without ID had increased risk of cancer, which may relate to common genetic pathways. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01