Methylation of the Glucocorticoid Receptor Gene Promoter in Preschoolers: Links with Internalizing Behavior Problems

Autor/inn/en	Parade, Stephanie H.; Ridout, Kathryn K.; Seifer, Ronald; Armstrong, David A.; Marsit, Carmen J.; McWilliams, Melissa A.; Tyrka, Audrey R.
Titel	Methylation of the Glucocorticoid Receptor Gene Promoter in Preschoolers: Links with Internalizing Behavior Problems
Quelle	In: Child Development, 87 (2016) 1, S.86-97 (12 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0009-3920
DOI	10.1111/cdev.12484
Schlagwörter	Preschool Children; Behavior Problems; Genetics; Psychopathology; Child Abuse; Interviews; Parents; Antisocial Behavior; Self Destructive Behavior; Early Experience; Structured Interviews + Suchen Sie Ihr Suchwort? Pre-school age; Preschool age; Child; Children; Pre-school education; Preschool education; Vorschulalter; Kind; Kinder; Vorschulkind; Vorschulkinder; Vorschulerziehung; Vorschule; Humangenetik; Psychopathologie; Abuse of children; Abuse; Kindesmissbrauch; Missbrauch; Interviewing; Interviewtechnik; Eltern; Self destrucive behaviour; Selbstzerstörung; Frühbeginn
Abstract	Accumulating evidence suggests that early adversity is linked to methylation of the glucocorticoid receptor (GR) gene, "NR3C1," which is a key regulator of the hypothalamic-pituitary-adrenal axis. Yet no prior work has considered the contribution of methylation of "NR3C1" to emerging behavior problems and psychopathology in childhood. This study examined the links between methylation of "NR3C1" and behavior problems in preschoolers. Data were drawn from a sample of preschoolers with early adversity (n = 171). Children ranged in age from 3 to 5 years, were racially and ethnically diverse, and nearly all qualified for public assistance. Seventy-one children had child welfare documentation of moderate to severe maltreatment in the past 6 months. Structured record review and interviews in the home were used to assess early adversity. Parents reported on child internalizing and externalizing behavior problems. Methylation of "NR3C1" at exons 1[subscript D], 1[subscript F], and 1[subscript H] were measured via sodium bisulfite pyrosequencing from saliva DNA. Methylation of "NR3C1" at exons 1[subscript D] and 1[subscript F] was positively associated with internalizing (r = 0.21, p < 0.01 and r = 0.23, p < 0.01, respectively), but not externalizing, behavior problems. Furthermore, "NR3C1" methylation mediated effects of early adversity on internalizing behavior problems. These results suggest that methylation of "NR3C1" contributes to psychopathology in young children, and "NR3C1" methylation from saliva DNA is salient to behavioral outcomes. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01