Altered Dynamics of the fMRI Response to Faces in Individuals with Autism

Autor/inn/en	Kleinhans, Natalia M.; Richards, Todd; Greenson, Jessica; Dawson, Geraldine; Aylward, Elizabeth
Titel	Altered Dynamics of the fMRI Response to Faces in Individuals with Autism
Quelle	In: Journal of Autism and Developmental Disorders, 46 (2016) 1, S.232-241 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-015-2565-8
Schlagwörter	Autism; Pervasive Developmental Disorders; Antisocial Behavior; Human Body; Fear; Brain; Diagnostic Tests; Comparative Analysis; Visual Stimuli; Brain Hemisphere Functions; Habituation + Suchen Sie Ihr Suchwort? Autismus; Menschlicher Körper; Furcht; Gehirn; Diagnostic test; Diagnostischer Test
Abstract	Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = 0.852, p < 0.001]. In contrast, habituation to houses had no predictive value (AUC = 0.573, p = 0.365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. (As Provided).
Anmerkungen	Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01