Literaturnachweis - Detailanzeige
| Autor/inn/en | Erickson, Craig A.; Wink, Logan K.; Early, Maureen C.; Stiegelmeyer, Elizabeth; Mathieu-Frasier, Lauren; Patrick, Vanessa; McDougle, Christopher J. |
|---|---|
| Titel | Brief Report: Pilot Single-Blind Placebo Lead-in Study of Acamprosate in Youth with Autistic Disorder |
| Quelle | In: Journal of Autism and Developmental Disorders, 44 (2014) 4, S.981-987 (7 Seiten)
PDF als Volltext |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0162-3257 |
| DOI | 10.1007/s10803-013-1943-3 |
| Schlagwörter | Autism; Pervasive Developmental Disorders; Drug Therapy; Metabolism; Physiology; Pathology; Children; Adolescents; Outcomes of Treatment; Symptoms (Individual Disorders); Social Behavior; Check Lists; Antisocial Behavior; Aberrant Behavior Checklist |
| Abstract | Rationale: An excitatory/inhibitory (E:I) imbalance marked by enhanced glutamate and deficient gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of autism spectrum disorders (ASD). Objectives: We report on the first single-blind placebo lead-in trial of acamprosate, a drug with putative mechanisms restoring E:I imbalance, in twelve youth with ASD. Materials and methods: We conducted a 12-week single-blind, placebo lead-in study of acamprosate in youth age 5-17 years with autistic disorder. Results: Six of nine subjects who received active drug treatment were deemed treatment responders (defined by a score at final visit of "very much improved" or "much improved" on the Clinical Global Impressions Improvement scale) and =25 % improvement on the Aberrant Behavior Checklist Social Withdrawal subscale. Conclusion: Future larger-scale dose finding studies of acamprosate in ASD may be warranted given this preliminary indication of benefit. (As Provided). |
| Anmerkungen | Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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