Adult Neurogenesis in the Mammalian Hippocampus: Why the Dentate Gyrus?

Autor/inn/en	Drew, Liam J.; Fusi, Stefano; Hen, René
Titel	Adult Neurogenesis in the Mammalian Hippocampus: Why the Dentate Gyrus?
Quelle	In: Learning & Memory, 20 (2013) 12, S.710-729 (20 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.026542.112
Schlagwörter	Brain Hemisphere Functions; Adults; Neurological Organization; Olfactory Perception; Neurology; Animals + Suchen Sie Ihr Suchwort? Neurologie; Animal; Tier; Tiere
Abstract	In the adult mammalian brain, newly generated neurons are continuously incorporated into two networks: interneurons born in the subventricular zone migrate to the olfactory bulb, whereas the dentate gyrus (DG) of the hippocampus integrates locally born principal neurons. That the rest of the mammalian brain loses significant neurogenic capacity after the perinatal period suggests that unique aspects of the structure and function of DG and olfactory bulb circuits allow them to benefit from the adult generation of neurons. In this review, we consider the distinctive features of the DG that may account for it being able to profit from this singular form of neural plasticity. Approaches to the problem of neurogenesis are grouped as "bottom-up," where the phenotype of adult-born granule cells is contrasted to that of mature developmentally born granule cells, and "top-down," where the impact of altering the amount of neurogenesis on behavior is examined. We end by considering the primary implications of these two approaches and future directions. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10