Reconsolidation May Incorporate State-Dependency into Previously Consolidated Memories

Autor/inn/en	Sierra, Rodrigo O.; Cassini, Lindsey F.; Santana, Fabiana; Crestani, Ana P.; Duran, Johanna M.; Haubrich, Josue; de Oliveira Alvares, Lucas; Quillfeldt, Jorge A.
Titel	Reconsolidation May Incorporate State-Dependency into Previously Consolidated Memories
Quelle	In: Learning & Memory, 20 (2013) 7, S.379-387 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.030023.112
Schlagwörter	Memory; Fear; Conditioning; Biochemistry; Brain; Drug Use; Experience; Animals + Suchen Sie Ihr Suchwort? Gedächtnis; Furcht; Biochemie; Gehirn; Drug consumption; Substance abuse; Drogenkonsum; Erfahrung; Animal; Tier; Tiere
Abstract	Some memories enter into a labile state after retrieval, requiring reconsolidation in order to persist. One functional role of memory reconsolidation is the updating of existing memories. There are reports suggesting that reconsolidation can be modulated by a particular endogenous process taking place concomitantly to its natural course, such as water or sleep deprivation. Here, we investigated whether an endogenous process activated during a natural/physiological experience, or a pharmacological intervention, can also contribute to memory content updating. Using the contextual fear conditioning paradigm in rats, we found that the endogenous content of an aversive memory can be updated during its reconsolidation incorporating consequences of natural events such as water deprivation, transforming a previously stored memory into a state-dependent one. This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation. Systemic morphine injection was also able to turn a previously acquired experience into a state-dependent memory, reproducing the very same effects obtained by water deprivation or local angiotensin II infusion, and suggesting that other state-dependent-inducing protocols would also be able to contribute to memory updating. These findings trigger new insights about the influence of ordinary daily life events upon memory in its continuing reconstruction, adding the realm of reconsolidation to the classical view of endogenous modulation of consolidation. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10